Abstract
Structure-activity relationship studies, focused on identification of the active pharmacophore fragments in a single high-throughput screening calcilytic hit, resulted in the discovery of potent calcium receptor antagonists, substituted 3H-quinazolin-4-ones.
MeSH terms
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Animals
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Male
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Models, Chemical
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Molecular Structure
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Osteoporosis / drug therapy
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Parathyroid Hormone / blood
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Quinazolines / chemistry*
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Quinazolines / pharmacology*
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Rats
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Rats, Sprague-Dawley
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Receptors, Calcium-Sensing / antagonists & inhibitors*
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Structure-Activity Relationship
Substances
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NPS53574
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Parathyroid Hormone
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Quinazolines
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Receptors, Calcium-Sensing